METHODS The ability of proteins in transgenic and non-transgenic soybeans, Brazil nuts, and purified 2S albumin to bind to IgE in serum from subjects allergic . Identification of a brazil-nut allergen in transgenic soybeans. J. A. Nordlee, S. L. Taylor, J. A. Townsend. Research output: Contribution to journal › Article. Background The nutritional quality of soybeans (Glycine max) is compromised by a relative deficiency of methionine in the protein fraction of the seeds.

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Jeffrey Smith Profile Page. Since the Brazil nut is a known allergenic food, we assessed the allergenicity of the 2S albumin. To be able to predict allergencity would be particularly useful as a part of the process of designing transgenes, but, currently, there are no models that would permit accurate assessment of allergenic potential of proteins unrelated to known allergens.


Identification of a Brazil-nut allergen in transgenic soybeans.

Sensitive people remain allergic to GM soybeans, but there is no additional allergenic risk to others. Altenbach 4 Estimated H-index: Platts-MillsWayne P. Recombinant plant-derived pharmaceuticals have been investigated for the last two decades and some products will soon be brought to market.

Identification of a Brazil-nut allergen in transgenic soybeans. Other Papers By First Author. Sun 5 Estimated H-index: The premarket safety system protects the consumer and the producer. This is exactly how the premarket safety assessment is supposed to help developers ensure that only products that are as safe as any other food reach the market. Evolutionary Genetic Engineering in the Indo-Pacific: Plant Food Protein Engineering.


The presence of so many distinct linear epitopes means that the probability of a naturally occurring variant with a sufficient number of alterations to disrupt the allergenicity is extremely small.

Oxford University Press is a department of the University of Oxford. I agree to the terms and conditions. Soybean protein is widely used in thousands of processed foods throughout the industrialized world and is a staple in Asia.

Pickardt 1 Estimated H-index: AstwoodJohn N.

The nutritional quality of soybeans Glycine max is compromised by a relative deficiency of methionine in the protein fraction of the seeds. Arshad 1 Estimated H-index: The epitope modification approach has been studied for peanut allergens and it does seem to be feasible to produce an essentially hypoallergenic variant.

Your comment will be reviewed and published at the journal’s discretion. Topics Discussed in This Paper. Citing articles via Web of Science Protein Measurement with the Folin Phenol Reagent. References Publications referenced by this paper.

Identification of a Brazil-nut allergen in transgenic soybeans. – Semantic Scholar

The potential of any new food to induce allergic reactions has been seized upon by critics of GM crops, which contain foreign or engineered proteins, and has been promulgated as an easily understandable concern that could transgenoc with consumers.

When Pioneer started this project the protein they selected was not known to be a potential allergen.


Showing of extracted citations. Allergenicity of various peanut products as determined by RAST inhibition. Ber e 1 protein: Calcium- and calmodulin-regulated microtubule-associated proteins as signal-integration hubs at the plasma membrane—cytoskeleton nexus.

Genetic Roulette Falsely Claims: Are you looking for Showing of 28 references. Alison Van Eenennaam Dr. Goodman Food and chemical toxicology: Brazil nut Bertholletia excelsa HBK proteins: Allergenicity and tolerance to proteins from Brazil nut Bertholletia excelsa H.

Identification of a brazil-nut allergen in transgenic soybeans

Soybeans have played a central role in concerns about GM introduced allergens and in using GM to remove intrinsic allergens. Goldman 10 Estimated H-index: Follow us on Twitter.

To improve the nutritional quality, methionine-rich 2S albumin from the Brazil nut Bertholletia excelsa trnsgenic been introduced into transgenic soybeans. It is not difficult to determine if a protein is a known food allergen.

Genetic Roulette Claim: A gene from a Brazil nut carried allergies into soybeans | Academics Review

Lucilia Helena Marcellino 5 Estimated H-index: This provides a model for further use of GM approaches to eliminate allergens. Topics Discussed in This Paper. Prospects for enhancing leaf photosynthetic capacity by manipulating mesophyll cells morphology.

HoffmanHayden LowensteinD. Receive exclusive offers and updates from Oxford Academic.

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