Interpolymer interactions between the countercharged polymers like Eudragit® EPO (polycation) and hypromellose acetate succinate. PDF | The objective of this investigation was to evaluate the potential of Eudragit EPO nanoparticles (EPO NP) in improving therapeutic efficacy. Download scientific diagram | Molecular structures of (a) MFA, (b) EUDRAGIT® EPO, and (c) EUDRAGIT® L from publication: Stabilization of a.

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The dissolution data of these matrices were fitted to different dissolution models. The aims of this study were as follows:. Conflict of Interest The authors report no conflict of interest.

Users requiring more precise data for scientific or engineering calculations can click on the property value to see the original value as well as raw conversions to equivalent units. To see MatWeb’s complete data sheet for this material including material property data, metal compositions, material suppliers, etcplease click the button below. The f 2 factor value was observed to be To clarify the release exponent for different batches of matrices, the log value of percentage drug released was plotted against log time for each batch according to the Eq.

It is well known that the release properties of polymeric carriers can be somehow predicted by the determination of their swelling and erosion characteristics J Biomed Mater Res. On the other hand, sustained drug release was observed in pH 6.


We advise that you only use the original value or one of its raw conversions in your calculations to minimize rounding error.

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Devi N, Maji TK. Hence, matrix tablets containing a combination of anionic and cationic polymers were prepared and the drug release profile was evaluated.

Influence of water soluble additives and HPMCP on drug release from Surelease-coated pellets containing tamsulosin hydrochloride. The percent degree of swelling was calculated as follows:. To describe the eidragit of drug release from the selected matrix formulation F8release data was analyzed according to different kinetic equations.

At each time of withdrawal, 10 mL of fresh medium was replaced into the dissolution flask.

The drug release profiles were compared using two model-independent methods, mean rpo time MDTand similarity factor f 2 Formulation with EE and EL F6 showed intermediate drug release profile compared to the other two polymer combinations.

J Appl Polym Sci. The manufactured tablets showed low weight variation indicating that the wet granulation method is an acceptable method for preparing good-quality matrix tablets. Data sheets for overmetals, plastics, ceramics, and composites. eudrafit

Tablets with mg of the polymers were compacted manually from the physical mixtures using a 9-mm punch in a tablet compression machine. Dissolution of tablets prepared using single polymer in a 0. Click here to view all the property values for this datasheet as they were originally entered into MatWeb.


Property Data This page displays only the text of a material data sheet. It is a white powder with a characteristic amine-like odour.

Evonik EUDRAGIT® E PO Copolymer

This might be due to the interaction of protonated dimethylamino group from EE with carboxylate group from anionic polymers. The data was analyzed by the regression coefficient method.

FT-IR spectrum of treated polymers. Blends of aqueous polymer dispersions used for pellet coating: HPMCP is cellulose in which some of the hydroxyl groups are replaced with methyl ethers, 2-hydroxypropyl ethers, or phthalyl esters. The non-Fickian release or anomalous transport of drug occurred when the n values are between the limiting values of Fickian and case II transport.

The percentage friability was calculated using the following equation:. Please review our privacy policy. To confirm the diffusion mechanism, the data was further fitted into Korsmeyer-Peppas equation

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