年1月23日 CalcuSyn is a software tool whose main purpose is to aid individuals in analyzing mixed drug treatments, a more and more used practice in. combination-index data generated by CalcuSyn software analyses .. and antagonism, respectively (Source: CalcuSyn manual, Biosoft, ). Manual and Software, Biosoft, Cambridge, U.K., Chou, T.-C. and Hayball , M. CalcuSyn for Windows, Multiple-drug dose-effect analyzer and manual.

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Chemotherapeutic synergism, potentiation and antagonism.

The uncertainties in dose are estimated using the algorithm described in the appendix: Application of the Chou-Talalay Method 15 Application of the Chou-Talalay Method Scope of Application Since both the median-effect equation of Chou and the combination-index equation of Chou-Talalay are general equations derived from the massaction law models, their derivations have rigorous mathematical proof and systematic documentation.

M, mM or IU can be combined and the results analyzed as usual. The plots drawn by CalcuSyn include dose-effect, median-effect, isobolograms and CI-effect.

A manula equation for dose-effect relationship derived by Chou 2 through mathematical induction using hundreds of enzyme kinetic models. BiophysDate: Note that in the two drug combination, the CI is the sum of three terms with the third term being the product of the first two terms.

It is essential to test the potency of a combination, before evaluation in the clinic, to prevent antagonistic actions.

Computer Software

Select a datapoint and select Edit to modify any values. The normalized isobologram shows the degrees of synergism or antagonism of each data point without showing the effect levels nor the actual dose or concentration levels.

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The estimated dose required to produce the given effect is displayed for a range of effect values. For simplicity, mutual exclusivity is usually assumed when more than two drugs are involved in combinations 8,9, A new experiment will then be created and the drug data imported.

Analysis of drug interactions.

The graph window shows a selection of graphs derived from the data. In this case, the component combinations can also be determined for their synergism or antagonism e.

CalcuSyn 34 View Reports Double-click the report in the contents tree that you want to open. Combination of more than Two Drugs For three drug combinations e. Thus, Dm and m parameters representing the potency and shape, respectively, determine the entire dose-effect curve. CalcuSyn 22 Step 3 – Now specify the drug data by clicking the Select button. Prined in the U.


You can get this from the Help About menu option. The file should be structured as calcusyj. Statistical Considerations 61 Statistical Considerations The median-effect equation is written thus: You are only able to import constant ratio drugs in this way. One of the most widely used ways to evaluate whether a combination is effective is the median-drug effect analysis method.

Click in the Monte Carlo processing box to enable Monte Carlo simulation. Dx 1 and Dx 2 in the denominators of Eq. Text can be copied from the window and pasted into a spreadsheet or word processor for further formatting or processing. Directly into the raw data grid 2.


The ratio of drugs in combinations has to be constant across mannual.

Analysis of drug interactions.

Nonetheless, it goes without saying that you still require some specialized knowledge in order to get around CalcuSyn. Using the Program 47 Data points mxnual However, this design will not provide Fa-CI plot simulation although the combination data points can be placed on the Fa-CI plot. CalcuSyn 40 You will then be able to see the tables and fields present in the source and select those to import.

The n can be partitioned into any combination of two parts which can be assigned to the two coordinates of the isobol 8. For combination drugs, the dose displayed is the dose of first component only – i.

Using the Program 43 Following the first line of each set which defines the set format the drug data is entered. This will open the raw data import dialog that lets you import either files or ODBC data.

Extensive Help contents are provided and thus, it becomes obvious that both power and novice users can find their way around it, without facing any kind of difficulties. The large majority of combination regimens are being developed empirically and there are few experimental studies designed to explore thoroughly different drug combinations, using appropriate methods of analysis.

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