Intrarenal control of renal function is by tubuloglomerular feedback and by glomerulotubular balance. In tubu- loglomerular feedback, Na/Cl delivery to the. Tubuloglomerular feedback is an adaptive mechanism that links the rate of glomerular . Intrinsic—Tubuloglomerular Feedback and Glomerulotubular Balance. Glomerulotubular Balance refers to the phenomenon whereby a constant layer of protection if mechanisms of tubuloglomerular feedback, that normalize rates.

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Glomerulotubular Balance

The size of the TGF response is directly dependent upon these changes. Tubuloglomerular feedback is one ablance several mechanisms the kidney uses to regulate glomerular filtration rate GFR.

The macula densa’s position enables it to rapidly alter afferent arteriolar resistance in response to changes in the flow rate through the distal nephron. Skip to main content.

Baroreflex Kinin—kallikrein system Renin—angiotensin system Vasoconstrictors Vasodilators Autoregulation Myogenic mechanism Tubuloglomerular feedback Cerebral autoregulation Paraganglia Aortic body Carotid body Glomus cell.

An increase in GFR causes a proportionate increase in fluid reabsorption from the proximal tubules and loop of Henle. Extracellular adenosine activates A1 receptors on vascular afferent arteriolar smooth muscle cells, resulting in vasoconstriction and a reduction in GFR Schnermann et al.

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The macula densa’s detection of elevated sodium chloride concentration in the tubular lumen, which leads to a decrease in GFR, is based on the concept of purinergic signaling. Thus, TGF-induced vasoconstriction is usually limited in magnitude. Significance Glomerulotubular balance is a critical mechanism which protects distal segments tubuliglomerular the nephron from being overloaded in contexts of short-term increases in GFR. The afferent arteriole cells release renin, leading to intrarenal angiotensin II formation.


Tubuloglomerular feedback – Wikipedia

A large sodium chloride concentration is indicative of an elevated GFR, while low sodium chloride concentration indicates a depressed GFR. The muscle tension in the afferent arteriole is modified based on the difference between the sensed concentration and a target concentration. The drop in GFR causes a tubuloglomerular feedback-mediated arteriolar dilation, restoring GFR and also increasing renal blood flow. Glomerulotubular balance can be thought of as an additional layer of protection if mechanisms of tubuloglomerular feedbackthat normalize rates of GFR, momentarily fail or are slow to be triggered.

In the physiology of the kidneytubuloglomerular feedback TGF is a feedback system inside the kidneys. American Journal of Physiology. Saunders, An Imprint of Elsevier. In other words, if the GFR spontaneously increases, the rate of water and solute resorption in the tubule proportionally increases, thus maintaining the same fraction the filtered load being resorbed. Pulse pressure Systolic Diastolic Mean arterial pressure Jugular venous pressure Portal venous pressure.

The macula densa uses the composition of the tubular fluid as an indicator of GFR.

The agents are vasoactive substances that alter either the magnitude or the sensitivity of the TGF response. A higher fluid flow rate in the TAL allows less time for dilution of the tubular fluid so that MD chloride concentration increases. The TGF mechanism is a negative feedback loop in which the chloride ion concentration is sensed downstream in the nephron by the macula densa MDcells in the tubular wall near the end of TAL and the glomerulus.


Journal of Mathematical Biology. Extracellular adenosine contributes to tubuloglomerulad regulation of GFR. Factors that increase TGF sensitivity include: Renal blood flow Ultrafiltration Countercurrent exchange Filtration fraction. Blood ablance Compliance Vascular resistance Pulse Perfusion.

Glomerulotubular balance, tubuloglomerular feedback, and salt homeostasis.

The macula densa is a collection of densely packed epithelial cells at the junction of the thick ascending blaance TAL and distal convoluted tubule DCT. From Wikipedia, the free encyclopedia. The critical target of the trans-JGA signaling cascade is the glomerular afferent arteriole; its response consists of an increase in net vasoconstrictor tone resulting in reductions of glomerular capillary pressure PGC tubuloglomeruar glomerular plasma flow.

A high protein diet affects the feedback activity by making the single nephron glomerular filtration rate higher, and the Na and Cl concentrations in early distal tubule fluid lower.

Increased GFR increases the oncotic pressure of the blood exiting the glomerulus. The kidney maintains the electrolyte concentrations, osmolality, and acid-base balance of blood plasma within the narrow limits that are compatible with effective cellular function; and the kidney participates in blood pressure regulation and in the maintenance of steady whole-organism water volume [4].

This consequently alters the balance of transcapillary fluid exchange in the peritubular capillary bed. Views Read Edit View history. Journal of the American Society of Nephrology.

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